Treatment of warts with podophyllotoxin

Many physicians use the substance podophyllotoxin to treat venereal warts. Podophyllin is actually a plant substance extracted from the plant podophyllum peltatum. For decades, it has been used as a medicinal compound by the North American Native Indians.

Podophyllotoxin actually prevents the wart cells from multiplying and dividing. Eventually all the wart cells die and the wart disappear.
Today Podophyllin is available only with a prescription and used as a cream or solution. It is not recommended to be used internally or for warts that are larger than a quarter.

In most cases, physicians apply the Podophyllin themselves and are reluctant to give out a prescription because the chemical is toxic. Once the skin is washed and completely dry, one should apply a cream on the normal skin. This is to prevent the Podophyllin from irritating normal skin. Then using a Q-tip the Podophyllin is applied and the wart is covered. The wart must be dry before applying the chemical. Podophyllin is applied twice a day for 3-4 consecutive days. In most cases, the treatment has to be repeated for several weeks.

In general, Podophyllin should not be applied for more than 5 weeks. Within this time period, most warts are gone. It is extremely important to make sure that the Podophyllin does not come into contact with the eyes, nose, mouth or healthy skin, inside the vagina, rectum or the urethra. If this happens, flush with water for 15-20 minutes. If inadvertent contact has been made with healthy skin, apply Vaseline or zinc ointment. Wash hands after each application and discard the Q-tip.

The first application of Podophyllin on the wart is painless but the subsequent applications do sting. This is because the wart is dying and the raw surface is exposed. Itching, pain and redness are common complaints. These effects are transient and can be reduced by applying some over the counter hydrocortisone.

Women who are pregnant or breast-feeding should not be treated with Podophyllin, as the safety of this agent has not been demonstrated on the fetus.

Podophyllin is a great drug for warts as long as one can tolerate the subsequent pain and discomfort.